Symbol
Name
ID

Tnfsf10
tumor necrosis factor (ligand) superfamily, member 10
MGI:107414

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

thymus hyperplasia

abnormal negative T cell selection

increased IgG1 level

increased IgG2a level

impaired natural killer cell mediated cytotoxicity

increased interferon-gamma secretion

increased interleukin-2 secretion

increased susceptibility to autoimmune diabetes

increased susceptibility to experimental autoimmune encephalomyelitis

increased susceptibility to induced arthritis

liver inflammation

decreased susceptibility to bacterial infection

decreased susceptibility to bacterial infection induced morbidity/mortality

Availability

Mouse Genotype

Tnfsf10^tm1Mjs/Tnfsf10^tm1Mjs

Tnfsf10^tm1Sdg/Tnfsf10^tm1Sdg

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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